A research team in Sweden examined the effects of a low-carb, isocaloric and hyperproteic diet of two weeks in 10 obese subjects with high fat content in the liver. Clinical analysis data were evaluated to determine changes in metabolism and in the intestinal bacterial population.
Subjects showed rapid and significant reductions in liver fat and other cardiometabolic risk factors, along with marked decreases in hepatic fat synthesis.
The mechanism is due to a reduction in the expression of genes involved in fatty acid synthesis and to an increase in the expression of genes involved in folate metabolism and in the oxidation of fatty acids.
More evidence on how a low carbohydrate diet improves metabolism and non-alcoholic fatty liver disease.
Adil Mardinoglu et al., An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.01.005