No. Food safety experts generally agree that there is no convincing evidence of a cause and effect relationship between these sweeteners and adverse health effects in humans. Aspartame did not show any adverse or allergic reactions in several clinical studies.
Some artificial sweeteners have the warning “phenylketonuria: contains phenylalanine” on the package. This warning indicates that people with phenylketonuria should not use them.
Phenylketonuria (PKU) is an autosomal recessive innate error in the metabolism of phenylalanine (Phe) resulting from the phenylalanine hydroxylase (PAH) deficiency. Untreated PKU is associated with an abnormal phenotype including growth failure, poor skin pigmentation, microcephaly, convulsions, delayed overall development and severe intellectual impairment.